I use a variety of programs! Photoshop CC is my go-to for drawings and paitings. I've been learning other painter programs like Corel and Clip Studio, but PS is my preferred.
For 3D its also a bit of a variety, my main program is Zbrush Core for just general sculpting; Marvelous designer for clothing. The modelling/retopo programs I use are Blender/Houdini. Going to be learning Substance painter soon, super excited to make some sick procedural textures
Heres a minion-fied Kahrun and Garnon I doodled for the aion discord a couple days ago